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The LDN Book, Volume Two

The Latest Research on How Low Dose Naltrexone Could Revolutionize Treatment for PTSD, Pain, IBD, Lyme Disease, Dermatologic Conditions, and More

By Linda Elsegood


A comprehensive examination of Low Dose Naltrexone – a little-known drug with big potential

New drug [LDN] raises hopes of reversing memory loss in old age the Guardian

A drug that is simultaneously affordable, devoid of severe side effects, and applicable to a wide range of diseases is not often found in the modern pharmaceutical landscape. But as medical professionals and researchers alike continue to discover, Low Dose Naltrexone (LDN) boasts this remarkable combination.

Expanding on the information presented in The LDN Book, Volume 1 – which showcased LDN’s efficacy in treating conditions such as lupus, thyroiditis, autism spectrum disorder, and chronic fatigue – Volume 2 highlights the latest clinical trials, case studies and research on LDN. More than a dozen medical professionals explain how they are using LDN to help patients suffering from:

  • Chronic pain
  • Parkinson’s disease
  • Dermatologic conditions
  • Traumatic brain injury 
  • Lyme disease and more.

Volume 1 and Volume 2 have been edited by Linda Elsegood, founder of the UK-based LDN Research Trust. Through the Trust and her work on the LDN books, Linda has connected thousands of patients, doctors and pharmacists around the world with information, articles and patient stories about LDN. The LDN Book, Volume 2 is a fantastic resource for practitioners, pharmacists and patients and a renewed call for further research on the healing potential of this beneficial drug.

Reviews and Praise

“Since the first volume of The LDN Book was released, I have had the distinct privilege of learning from and collaborating with the best clinicians and researchers in the field of integrative medicine. Through these collaborations, we continue to build upon the already vast applications of this low-dose but high-power medication. I am thrilled to see so many trusted colleagues, who have also become friends, contribute to this important body of work. Thank you, again, Linda Elsegood, for bringing together a tribe of like-minded people who continue to find solutions to challenging medical issues with this simple and inexpensive intervention.”—Dr. Nasha Winters, ND, FABNO, author of The Metabolic Approach to Cancer

“As a pharmacist, I often wish for a ‘miracle’ drug that would be safe, effective, and inexpensive and could help the masses take back their health. While no drug is right for everyone, I have seen LDN transform the lives of countless people with autoimmunity. For some, LDN has truly been a miracle drug. I highly recommend both volumes of The LDN Book as valuable resources for patients and clinicians alike to explore the best practices for using LDN.”—Dr. Izabella Wentz, Pharm.D., FASCP, New York Times bestselling author of Hashimoto’s Protocol

“A fantastic resource. All the latest research on low dose naltrexone and its various uses in clinical practice is compiled in this easy-to-use volume—The LDN Book, Volume 2. I will definitely be keeping this book in my office for reference.”—Jill C. Carnahan, MD, ABIHM, ABoIM, IFMCP

“Even if you think you know about the benefits of LDN for certain conditions through practical experience or otherwise, this book will expand your understanding and amazement. It is a remarkable finding that a drug designed for a specific condition can be applied to so many other systems at lower and lower doses. Interestingly, this has shown us that many other drugs may also have unexpected benefits at lower-than-intended doses. There are many layers of complexity that remain to be uncovered!”—Dr. Angus Dalgleish, professor of oncology, St. George’s, University of London; principal, Institute for Cancer Vaccines and Immunotherapy (ICVI)

“Over the years, a wealth of clinical trials and studies on LDN have given us better information about how and why LDN actually works. Through this research, we have uncovered many new uses of LDN in medical treatment. Reviewing The LDN Book, Volume 2 and seeing how other experts prescribe LDN in their clinics has been a great treat for me. My clinic, Clinic 158, has been prescribing LDN for 12 years. We have thousands of very happy patients who have found success with the medication for a myriad of ailments, and we are still learning new information.”—Dr. Andrew McCall, director, Clinic 158

“Since inflammation is a major contributor to almost all chronic disorders, LDN therapy bridges nearly every medical specialty. In The LDN Book, Volume 2, the authors provide an excellent overview of LDN’s mechanism of action, review the vast evidence base supporting clinical applications, and, most importantly, report actual cases in which LDN was instrumental in the successful treatment of patients. This book is a must-have for every clinician, and LDN should be considered in the treatment of the many disorders outlined therein.”—Sahar Swidan, Pharm.D., R.Ph., ABAAHP, FAARFM, FACA, president and CEO, Pharmacy Solutions

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The LDN Book cover

The LDN Book

Linda Elsegood


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